ASIC4 | |||||||||||||||||
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Identifiers | |||||||||||||||||
Aliases | ASIC4, ACCN4, BNAC4, acid sensing ion channel subunit family member 4 | ||||||||||||||||
External IDs | MGI: 2652846 HomoloGene: 11166 GeneCards: 55515 | ||||||||||||||||
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Species | Human | Mouse | |||||||||||||||
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Location (UCSC) | Chr 2: 219.51 – 219.54 Mb | Chr 1: 75.45 – 75.47 Mb | |||||||||||||||
PubMed search | [1] | [2] | |||||||||||||||
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Amiloride-sensitive cation channel 4 also known as amiloride-sensitive cation channel 4, neuronal (ACCN4) or amiloride-sensitive cation channel 4, pituitary or acid-sensing ion channel 4 (ASIC4) is a membrane protein that in humans is encoded by the ACCN4 gene. The ASIC4 protein is a member of the acid-sensing ion channel family that is expressed in the pituitary gland and other parts of the brain. ASIC4 may have lost its ion transport function[3] but play a regulatory role through interactions with other members of the family[4] or other proteins.[5][6]
Function
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.[6]
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Ishikita H (2011). Wanunu M, ed. "Proton-binding sites of acid-sensing ion channel 1". PLoS ONE. 6 (2): e16920. doi:10.1371/journal.pone.0016920. PMC 3038902. PMID 21340031.
- ^ Chen X, Polleichtner G, Kadurin I, Gründer S (2007). "Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+". J. Biol. Chem. 282 (42): 30406–13. doi:10.1074/jbc.M702229200. PMID 17686779.
- ^ Donier E, Rugiero F, Jacob C, Wood JN (2008). "Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay". Eur. J. Neurosci. 28 (1): 74–86. doi:10.1111/j.1460-9568.2008.06282.x. PMID 18662336.
- ^ a b "Entrez Gene: amiloride-sensitive cation channel 4".
Further reading
- Donier E, Rugiero F, Jacob C, Wood JN (2008). "Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay". Eur. J. Neurosci. 28 (1): 74–86. doi:10.1111/j.1460-9568.2008.06282.x. PMID 18662336.
- Gründer S, Geissler HS, Bässler EL, Ruppersberg JP (2000). "A new member of acid-sensing ion channels from pituitary gland". NeuroReport. 11 (8): 1607–11. doi:10.1097/00001756-200006050-00003. PMID 10852210.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Gründer S, Geisler HS, Rainier S, Fink JK (2001). "Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia". Eur. J. Hum. Genet. 9 (9): 672–6. doi:10.1038/sj.ejhg.5200699. PMID 11571555.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.