The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3gene.[1] NOR1 is a member of the nuclear receptor family of intracellulartranscription factors.
^Hedvat CV, Irving SG (1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Mol. Endocrinol.9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID8614405.
^Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID16901967.
^Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID18325999.
^Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (January 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Res.63 (2): 449–54. PMID12543801.
^Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Dev. Neurosci.23 (1): 17–24. doi:10.1159/000048692. PMID11173923.
Further reading
Ohkura N, Hijikuro M, Yamamoto A, Miki K (1995). "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells". Biochem. Biophys. Res. Commun.205 (3): 1959–65. doi:10.1006/bbrc.1994.2900. PMID7811288.
Clark J, Benjamin H, Gill S et al. (1996). "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma". Oncogene12 (2): 229–35. PMID8570200.CS1 maint: Explicit use of et al. (link)
Labelle Y, Zucman J, Stenman G et al. (1996). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation". Hum. Mol. Genet.4 (12): 2219–26. doi:10.1093/hmg/4.12.2219. PMID8634690.CS1 maint: Explicit use of et al. (link)
Ohkura N, Ito M, Tsukada T et al. (1996). "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family". Biochim. Biophys. Acta1308 (3): 205–14. doi:10.1016/0167-4781(96)00101-7. PMID8809112.CS1 maint: Explicit use of et al. (link)
Ohkura N, Ito M, Tsukada T et al. (1998). "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA". Gene211 (1): 79–85. doi:10.1016/S0378-1119(98)00095-X. PMID9573341.CS1 maint: Explicit use of et al. (link)
Labelle Y, Bussières J, Courjal F, Goldring MB (1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator". Oncogene18 (21): 3303–8. doi:10.1038/sj.onc.1202675. PMID10359536.
Panagopoulos I, Mencinger M, Dietrich CU et al. (2000). "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11)". Oncogene18 (52): 7594–8. doi:10.1038/sj.onc.1203155. PMID10602519.CS1 maint: Explicit use of et al. (link)
Sjögren H, Wedell B, Meis-Kindblom JM et al. (2001). "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)". Cancer Res.60 (24): 6832–5. PMID11156374.CS1 maint: Explicit use of et al. (link)
Liu D, Jia H, Holmes DI et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol.23 (11): 2002–7. doi:10.1161/01.ATV.0000098644.03153.6F. PMID14525795.CS1 maint: Explicit use of et al. (link)
Rius J, Martínez-González J, Crespo J, Badimon L (2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB". Arterioscler. Thromb. Vasc. Biol.24 (4): 697–702. doi:10.1161/01.ATV.0000121570.00515.dc. PMID14962944.
Hisaoka M, Okamoto S, Yokoyama K, Hashimoto H (2004). "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes". Cancer Genet. Cytogenet.152 (2): 101–7. doi:10.1016/j.cancergencyto.2003.11.011. PMID15262426.
Laflamme C, Filion C, Labelle Y (2005). "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1". Hum. Mutat.24 (6): 502–8. doi:10.1002/humu.20102. PMID15523651.
Pei L, Castrillo A, Chen M et al. (2005). "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli". J. Biol. Chem.280 (32): 29256–62. doi:10.1074/jbc.M502606200. PMID15964844.CS1 maint: Explicit use of et al. (link)
Bonta PI, van Tiel CM, Vos M et al. (2006). "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses". Arterioscler. Thromb. Vasc. Biol.26 (10): 2288–94. doi:10.1161/01.ATV.0000238346.84458.5d. PMID16873729.CS1 maint: Explicit use of et al. (link)
Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID16901967.
Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID18325999.
Vacca M, Murzilli S, Salvatore S et al. (2013). "Neuron-derived orphan receptor 1 promotes proliferation of quiescent hepatocytes". Gastroenterology144 (7): 1518–1529. doi:10.1053/j.gastro.2013.02.027. PMID23462179.CS1 maint: Explicit use of et al. (link)