Brevican core protein is a protein that in humans is encoded by the BCANgene.[1][2][3] Brevican is a member of the lectican protein family.
In melanocytic cells BCAN gene expression may be regulated by MITF.[4]
References
^Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Dec 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene256 (1-2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID11054543.
^Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Mar 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Med Okayama56 (1): 25–9. PMID11873941.
Seidenbecher CI, Richter K, Rauch U et al. (1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms.". J. Biol. Chem.270 (45): 27206–12. doi:10.1074/jbc.270.45.27206. PMID7592978.
Nakamura H, Fujii Y, Inoki I et al. (2001). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.". J. Biol. Chem.275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID10986281.
Olin AI, Mörgelin M, Sasaki T et al. (2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.". J. Biol. Chem.276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID11038354.
Xu XM, Chen Y, Chen J et al. (2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis.". Cancer Res.63 (18): 5685–90. PMID14522884.
Bekku Y, Su WD, Hirakawa S et al. (2004). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.". Mol. Cell. Neurosci.24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID14550776.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Dong Y, Han X, Xue Y et al. (2004). "Secreted brevican mRNA is expressed in the adult rat pituitary.". Biochem. Biophys. Res. Commun.314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID14741698.
Viapiano MS, Bi WL, Piepmeier J et al. (2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas.". Cancer Res.65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID16061654.
Nakada M, Miyamori H, Kita D et al. (2007). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican.". Acta Neuropathol.110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID16133547.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network.". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.