Systematic (IUPAC) name | |
---|---|
3-hydroxy-1,2-dimethylpyridin-4(1H)-one | |
Identifiers | |
CAS number | 30652-11-0 |
ATC code | V03AC02 |
PubChem | CID 2972 |
ChemSpider | 2866 |
Chemical data | |
Formula | C7H9NO2 |
Mol. mass | 139.152 g/mol |
SMILES | eMolecules & PubChem |
Pharmacokinetic data | |
Metabolism | Glucuronidation |
Half-life | 2 to 3 hours |
Excretion | Renal (75 to 90% in 24 hours) |
Therapeutic considerations | |
Licence data | |
Pregnancy cat. | ? |
Legal status | |
Routes | Oral |
Deferiprone (tradenames include Ferriprox) is an oral drug that chelates iron and is used to treat thalassaemia major.[1]
It is currently licensed for use in Europe and Asia, but not in Canada and the United States.[1]
Controversy
Deferiprone was at the center of a protracted struggle between Nancy Olivieri, a Canadian haematologist and researcher, and the Hospital for Sick Children and pharmaceutical giant Apotex, that started in 1996.[2] Dr. Olivieri's data suggested that deferiprone leads to progressive hepatic fibrosis, a finding which is in dispute.[3][4]
References
- ^ a b Savulescu J (2004). "Thalassaemia major: the murky story of deferiprone". BMJ 328 (7436): 358–9. doi:10.1136/bmj.328.7436.358. PMID 14962851. Full Text.
- ^ Viens A, Savulescu J (2004). "Introduction to The Olivieri symposium.". J Med Ethics 30 (1): 1–7. doi:10.1136/jme.2003.006577. PMID [http://jme.bmj.com/cgi/content/full/30/1/1 Free Full Text 14872065. [http://jme.bmj.com/cgi/content/full/30/1/1 Free Full Text]].
- ^ Brittenham G, Nathan D, Olivieri N, Porter J, Pippard M, Vichinsky E, Weatherall D (2003). "Deferiprone and hepatic fibrosis". Blood 101 (12): 5089–90; author reply 5090–1. doi:10.1182/blood-2002-10-3173. PMID 12788794. Full Text.
- ^ Wanless I, Sweeney G, Dhillon A, Guido M, Piga A, Galanello R, Gamberini M, Schwartz E, Cohen A (2002). "Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia". Blood 100 (5): 1566–9. doi:10.1182/blood-2002-01-0306. PMID 12176871. Full Text.
See also
|