Protein-coding gene in the species Homo sapiens
Ras-interacting protein 1 (Rain) , is a protein that in humans is encoded by the RASIP1 gene .[5]
Function
Clinical significance
A recent genome-wide association study (GWAS) has found that genetic variations in RASIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD) . However, it's unknown how RASIP1 mutation contributes to disease.[12]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000105538 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044562 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein" . www.uniprot.org . Retrieved 2021-12-11 . Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License .
^ Wilson CW, Ye W (2014). "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling" . Cell Adhesion & Migration . 8 (2): 76–83. doi :10.4161/cam.28115 . PMC 4049864 . PMID 24622510 .
^ Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, et al. (April 2016). "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth" . Angiogenesis . 19 (2): 173–190. doi :10.1007/s10456-016-9498-5 . PMC 4808411 . PMID 26897025 .
^ Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, et al. (August 2018). "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions" . Development . 145 (17): dev165092. doi :10.1242/dev.165092 . PMC 6141773 . PMID 30042182 .
^ Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O (May 2009). "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation" . Developmental Biology . 329 (2): 269–279. doi :10.1016/j.ydbio.2009.02.033 . PMC 2683470 . PMID 19272373 .
^ Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, et al. (September 2016). "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II" . Circulation Research . 119 (7): 810–826. doi :10.1161/CIRCRESAHA.116.309094 . PMC 5026621 . PMID 27486147 .
^ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization" . The Journal of Biological Chemistry . 279 (21): 22353–22361. doi :10.1074/jbc.M312867200 . PMID 15031288 .
^ Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease" . Nature Genetics . 53 (9): 1276–1282. doi :10.1038/s41588-021-00921-z . hdl :1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488 . PMC 10243600 . PMID 34493870 . S2CID 237442349 .