Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3gene.[3][4]
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.[4]
Huang SL, Shyu RY, Yeh MY, Jiang SY (2000). "Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells". Mol. Cell. Endocrinol. 159 (1–2): 15–24. doi:10.1016/S0303-7207(99)00207-5. PMID10687848. S2CID11139637.
Duvic M, Helekar B, Schulz C, et al. (2000). "Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer". Clin. Cancer Res. 6 (8): 3249–59. PMID10955811.
Deucher A, Nagpal S, Chandraratna RA, et al. (2001). "The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity". Int. J. Oncol. 17 (6): 1195–203. doi:10.3892/ijo.17.6.1195. PMID11078805.
Yoneyama M, Kikuchi M, Natsukawa T, et al. (2004). "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses". Nat. Immunol. 5 (7): 730–7. doi:10.1038/ni1087. PMID15208624. S2CID34876422.
Jiang SY, Wu MS, Chen LM, et al. (2005). "Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter". Biochem. Biophys. Res. Commun. 331 (2): 630–9. doi:10.1016/j.bbrc.2005.03.214. PMID15850806.