中国科学院武汉病毒研究所 | |
Abbreviation | WIV |
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Predecessor |
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Formation | 1956 |
Founder | Chen Huagui, Gao Shangyin |
Headquarters | Xiaohongshan, Wuchang District, Wuhan, Hubei |
Coordinates | 30°22′35″N 114°15′45″E / 30.37639°N 114.26250°E |
Director-General | Wang Yanyi |
Secretary of Party Committee | Xiao Gengfu[1] |
Deputy Director-General | Gong Peng, Guan Wuxiang, Xiao Gengfu |
Parent organization | Chinese Academy of Sciences |
Website | whiov.cas.cn |
Wuhan Institute of Virology | |||||||
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Simplified Chinese | 中国科学院武汉病毒研究所 | ||||||
Traditional Chinese | 中國科學院武漢病毒研究所 | ||||||
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The Wuhan Institute of Virology, Chinese Academy of Sciences (WIV; Chinese: 中国科学院武汉病毒研究所) is a research institute on virology administered by the Chinese Academy of Sciences (CAS). Located in Jiangxia District, Wuhan, Hubei, it opened mainland China's first biosafety level 4 (BSL–4) laboratory in 2015.[2] The Institute has strong ties to the Galveston National Laboratory in the United States, the Centre International de Recherche en Infectiologie in France and the National Microbiology Laboratory in Canada.
In January 2020, conspiracy theories circulated that the COVID-19 pandemic originated from viruses engineered by the WIV, which were refuted on the basis of scientific evidence that the virus has natural origins.[3][4][5][6][7] In mid-January, U.S. intelligence agencies reported to U.S. officials that they had not detected any alarm within the Chinese government that would suggest the outbreak had emerged from a government laboratory.[8] In an opinion column in the Washington Post, Josh Rogin wrote that US State Department cables from 2018 raised safety concerns about WIV's research on bat coronaviruses.[9] In April 2020, at the request of Trump administration officials, U.S. intelligence agencies began investigating whether the outbreak originated from the accidental exposure by WIV scientists studying natural coronaviruses in bats.[10][8][11] The New York Times reported that senior officials in the Trump administration were pressuring intelligence agencies to find evidence for the unsubstantiated theory that the virus leaked from the laboratory, leading to concern among some intelligence analysts that intelligence assessments would be distorted to serve a political campaign to lay blame on China for the outbreak.[12]
Leading virologists have disputed the idea that SARS-CoV-2 leaked from the institute.[13][14] The virologist Peter Daszak, president of the EcoHealth Alliance, which studies emerging infectious diseases, has had a 15 year collaboration with Shi Zhengli, a leading WIV virologist, to study bat coronaviruses.[15] Daszak has noted estimates that 1-7 million people in Southeast Asia who live or work in proximity to bats are infected each year with bat coronaviruses.[13][14] In an interview with Vox, Daszak comments, "There are probably half a dozen people that do work in those labs. So let's compare 1 million to 7 million people a year to half a dozen people; it's just not logical."[14] Jonna Mazet, Professor of epidemiology at the University of California, Davis and director of the PREDICT project to monitor emerging viruses, has commented that staff at the Wuhan Institute of Virology were trained by U.S. scientists as part of the PREDICT program and follow high safety standards, and that "All of the evidence points to this not being a laboratory accident."[13]
History
The WIV was founded in 1956 as the Wuhan Microbiology Laboratory under the Chinese Academy of Sciences (CAS). In 1961, it became the South China Institute of Microbiology, and in 1962 was renamed Wuhan Microbiology Institute. In 1970, it became the Microbiology Institute of Hubei Province when the Hubei Commission of Science and Technology took over the administration. In June 1978, it was returned to the CAS and renamed Wuhan Institute of Virology.[16]
In 2015, the WIV's National Bio-safety Laboratory was completed at a cost of 300 million yuan ($44 million) in collaboration with the French government's CIRI lab, and was the first biosafety level 4 (BSL–4) laboratory to be built in mainland China.[2][17] The establishment of the laboratory was partially funded by the U.S. government and took over a decade to complete from its conception in 2003.[2]
The Laboratory has strong ties to the Galveston National Laboratory in the University of Texas.[3] It also had strong ties with Canada's National Microbiology Laboratory until WIV staff scientists Xiangguo Qiu and her husband Keding Cheng, who were also remunerated by the Canadian government, were escorted from the Canadian lab for undisclosed reasons in July 2019.[18]
The WIV has been a topic of controversy since the start of reporting of the COVID-19 pandemic. Scientists such as U.S. molecular biologist Richard H. Ebright, who had expressed concern of previous escapes of the SARS virus at Chinese laboratories in Beijing and had been troubled by the pace and scale of China's plans for expansion into BSL–4 laboratories,[2] called the Institute a "world-class research institution that does world-class research in virology and immunology" while he noted that the WIV is a world leader in the study of bat coronaviruses.[3]
In 2005, a group including researchers from the Wuhan Institute of Virology published research into the origin of the SARS coronavirus, finding that China's horseshoe bats are natural reservoirs of SARS-like coronaviruses.[19] Continuing this work over a period of years, researchers from the Institute sampled thousands of horseshoe bats in locations across China, isolating over 300 bat coronavirus sequences.[20]
In 2015, an international team including two scientists from the Institute published successful research on whether a bat coronavirus could be made to infect HeLa. The team engineered a hybrid virus, combining a bat coronavirus with a SARS virus that had been adapted to grow in mice and mimic human disease. The hybrid virus was able to infect human cells.[21][22]
In 2017, a team from the Institute announced that coronaviruses found in horseshoe bats at a cave in Yunnan contain all the genetic pieces of the SARS virus, and hypothesized that the direct progenitor of the human virus originated in this cave. The team, who spent five years sampling the bats in the cave, noted the presence of a village only a kilometer away, and warned of "the risk of spillover into people and emergence of a disease similar to SARS".[20][23]
In 2018, another paper by a team from the Institute reported the results of a serological study of a sample of villagers residing near these bat caves (near Xiyang Township 夕阳乡 in Jinning District of Yunnan). According to this report, 6 out of the 218 local residents in the sample carried antibodies to the bat coronaviruses in their blood, indicating the possibility of transmission of the infections from bats to people.[24]
COVID-19 pandemic
In December 2019, cases of pneumonia associated with an unknown coronavirus were reported to health authorities in Wuhan. The Institute checked its coronavirus collection and found the new virus was 96 percent identical to a sample its researchers had taken from horseshoe bats in southwest China.[25]
As the virus spread worldwide, the Institute continued its investigation. In February 2020, the New York Times reported that a team led by Shi Zhengli at the Institute were the first to identify, analyze and name the genetic sequence of the novel coronavirus (2019-nCoV), and upload it to public databases for scientists around the world to understand,[26][27] and publishing papers in Nature.[28] On 19 February, 2020, the lab released a letter on its website describing how they successfully obtained the whole virus genome: "On the evening of December 30, 2019, after receiving the unexplained pneumonia samples sent by Wuhan Jinyintan Hospital, our institute organized the strength overnight and worked for 72 hours to solve the problem. On January 2, 2020, the whole genome sequence of the new coronavirus was determined".[29] In February 2020, the Institute applied for a patent in China for the use of remdesivir, an experimental drug owned by Gilead Sciences, which the Institute found inhibited the virus in vitro;[30] in a move that raised concerns regarding intellectual property rights.[31] The WIV said it would not exercise its new Chinese patent rights "if relevant foreign companies intend to contribute to the prevention and control of China’s epidemic".[32]
Concerns as source
In January 2020, conspiracy theories emerged that the Institute was a source for the COVID-19 pandemic as a result of allegations of bioweapon research, a concept that scientists have rejected, noting that the Institute was not suitable for bioweapon research, that most countries had abandoned bioweapons as fruitless, and that there was no evidence that the virus was genetically engineered.[33][5][6][7][4] U.S. Deputy National Security Advisor, Matthew Pottinger, pressed intelligence agencies to find evidence for the theory, but was told that they had no evidence to support it.[8] Intelligence agencies informed Pottinger that they had not detected any signs of alarm within the Chinese government that would point towards an accident at the laboratory.[8] In February 2020, virus expert and global lead coronavirus investigator Trevor Bedford observed that "The evidence we have is that the mutations [in the virus] are completely consistent with natural evolution".[34]
During January and February 2020, the Institute was subject to further theories, and concerns that it was the source of the outbreak through accidental leakage,[35] which it publicly argued was not the case.[36] Members of the Institute's research teams were also the subject of various theories,[37][38] including Shi Zhengli, who made various public statements defending the Institute.[39] While Ebright refuted several of theories regarding the WIV, he told BBC China that this did not represent the possibility of the virus being "completely ruled out" from entering the population due to a laboratory accident.[35] Leading virologists rejected the theory of an accidental leak, pointing to the strong safety standards of the Wuhan Institute of Virology and the overwhelming probability that the virus emerged from contact between humans and animals outside the laboratory.[13][14]
On March 11, Scientific American reported that Shi Zhengli, the lead researcher at WIV, looked through lab records for any possible mishandling of experimental materials, especially during disposal. She also cross-checked the novel coronavirus genome against genetic information of other bat coronaviruses her team had collected. She found that SARS-CoV-2 does not match any virus her team had sampled from bat caves.[40] Immunologist Vincent Racaniello stated that virus leaking theory "reflect a lack of understanding of the genetic make-up of Sars-CoV-2 and its relationship to the bat virus". He states that the bat virus researched in the institution "would not have been able to infect humans – the human Sars-CoV-2 has additional changes that allows it to infect humans."[41]
While the lab leakage claims were reported in mainstream media in the United States,[42][9] these claims drew criticism from several scientists, including Columbia University virologist Angela Rasmussen, who described the publishers of such as "irresponsible" for failing to consult virologists prior to publication. Rasmussen is concerned that these types of charges will damage international scientific collaboration. “We live in a global world,” she said. “It would hurt us tremendously if we were to stop collaborating with Chinese scientists.”[43] Various researchers contacted by NPR concluded that it is highly unlikely that the pandemic virus had accidentally escaped from a laboratory.[13]
During a 15 April 2020 White House news conference, US President Donald Trump said the U.S. government was trying to determine if the COVID-19 virus emanated from the WIV,[44][45] and the Trump Administration subsequently launched examinations into the unverified reports that the virus may have originated from accidental exposure of scientists studying natural coronaviruses in bats at the Wuhan Institute of Virology.[10][11] Regarding the origin of the COVID-19 virus, Deborah Birx, the Coronavirus Response Coordinator for the Trump Administration's White House Coronavirus Task Force, stated 19 April on CBS Face the Nation that she does not know precisely where it originated, and right now, "the general consensus is animal to human".[46]
On 30 April 2020, The New York Times reported that the Trump administration had demanded that intelligence agencies find evidence to support the theory that SARS-Cov-2 originated from the WIV. Secretary of State and former Central Intelligence Agency (CIA) director Mike Pompeo was reportedly leading the push on finding information regarding the virus origin. Analysts were concerned that pressure from senior officials could distort assessments from the intelligence community. Anthony Ruggiero, the head of the National Security Council which responsible for tracking weapons of mass destruction, expressed frustration during a video conference that CIA was unable to form conclusive answer on the origin of the virus. According to current and former government officials, as of April 30, CIA has yet to gather any information beyond circumstantial evidence to bolster the lab theory.[47][48] US intelligence officers suggested that Chinese officials tried to conceal the severity of the outbreak in early days, but no evidence had shown China attempted to cover up a lab accident.[49]
On 30 April 2020, Trump claimed to have evidence of the lab theory, but offered no further details.[50][51] In a news conference, Trump stated he had seen classified evidence that gave him "a high degree of confidence" that the virus originated at the WIV.[52] Similarly, US Secretary of State Mike Pompeo claimed on 3 May that there is "enormous evidence" the coronavirus outbreak originated in a Chinese laboratory.[53] In mid-May, Pompeo appeared to back away from the theory, telling Breitbart News that "we know it began in Wuhan, but we don't know from where or from whom, and those are important things."[54] Beijing rejected the White House's claim, calling the claim "part of an election year strategy by President Donald Trump’s Republican Party".[55] Hua Chunying, Chinese Foreign Ministry spokeswoman, urged Mike Pompeo to present evidence for his claim. "Mr. Pompeo cannot present any evidence because he does not have any," Hua told a journalist during a regular briefing, "This matter should be handled by scientists and professionals instead of politicians out of their domestic political needs."[55] The Chinese ambassador, in an opinion published in the Washington Post, called on the White House to end the "blame game" over the coronavirus.[56][57]
The behaviour of the Chinese government has "fueled theories that the virus accidently leaked from [the WIV]."[58][59][60] There is however no evidence backing the conspiracy claims,[58] with scientists noting that "the available data argue overwhelmingly against any scientific misconduct or negligence".[61] Virologists interviewed by NPR have said that there is virtually no chance that the virus emerged from a lab.[13]
Research centers
The Institute contains the following research centers:[62]
- Center for Emerging Infectious Disease
- Chinese Virus Resources and Bioinformatics Center
- Center of Applied and Environmental Microbiology
- Department of Analytical Biochemistry and Biotechnology
- Department of Molecular Virology
See also
- Chinese Center for Disease Control and Prevention
- Misinformation related to the COVID-19 pandemic
- Shi Zhengli, lead virologist
- Zoonosis
References
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External links