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: {{done}} For the record, the new links often don't work for me either, but they sometimes do and it's clearly better than the old completely-broken ones. [[User:Pppery|* Pppery *]] [[User talk:Pppery|<sub style="color:#800000">it has begun...</sub>]] 21:42, 4 September 2023 (UTC) |
: {{done}} For the record, the new links often don't work for me either, but they sometimes do and it's clearly better than the old completely-broken ones. [[User:Pppery|* Pppery *]] [[User talk:Pppery|<sub style="color:#800000">it has begun...</sub>]] 21:42, 4 September 2023 (UTC) |
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== Global Substance Registration System - GSRS == |
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Please consider adding [https://gsrs.ncats.nih.gov/ginas/app/beta/home GSRS] to the infobox. |
Please consider adding [https://gsrs.ncats.nih.gov/ginas/app/beta/home GSRS] to the infobox. |
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Revision as of 18:02, 24 September 2023
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Infobox drug: Changes log
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FDA search fails, but does not return an error
The URL generated for the license_US
parameter does not appear to work anymore. Repeating the approach under § INN link for EMA does not work, I'll use the URL generated for Aspirin as an example: https://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchTerm=Aspirin&SearchType=BasicSearch.
This redirects to the search interface, https://www.accessdata.fda.gov/scripts/cder/daf/. I figured maybe query string parameters had just changed, so I checked how requests are encoded.
When I searched for "Aspirin" today, the request URL was https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process
.
The request payload:
Key | Value |
---|---|
event |
BasicSearch.process
|
searchterm |
Aspirin
|
search |
I naively tried https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?fuseaction=BasicSearch.process&searchterm=aspirin
, to no avail. Perhaps if I were at all familiar with CFML I'd have a better strategy, but I figured it was worth a shot.
-- Spida-tarbell (talk) 03:27, 23 March 2023 (UTC)
- Prior discussions here, here, and here --Whywhenwhohow (talk) 06:20, 23 March 2023 (UTC)
- I see now, thanks. I apologize for not having searched through archives first! For an ongoing problem, would it still make sense to make a new topic, but additionally link to relevant archives for reference? I'm fairly new to editing, and I appreciate the time you spent here. Spida-tarbell (talk) 17:21, 23 March 2023 (UTC)
- Whyw is not reproaching you for not searching ;-) they are correctly noting earlier, fruitless talks. Meanwhile, I hope we can make it work this time, see #Infobox drug FDA link below. Still, their site is hard to analyse. Which data do we expect? DePiep (talk) 17:53, 23 March 2023 (UTC)
- Thank you! So, what's tricky is that the original encoding linked to a search for the drug on the FDA website. Now, it seems that the only URL we can rely on is one that encodes the New Drug Application (NDA) ID in the URL, but this only applies to a particular instance (e.g. GlaxoSmithKline's Excedrin Migraine, NDA 020802.
- Maybe someone else would fare better figuring out a working search URL for the new implementation, or I could contact the agency to ask whether such a possibility exists. – Spida-tarbell (talk) 18:54, 1 April 2023 (UTC)
- Below are the 22 pages FDA provides (blue bar, collapsed). None has this solution.
- Point is: how to learn the NDA key (020802 in your example), automated? Is it published? (Usually, the site itself published how to retrieve such info). We cannot rely on the reader having top type the right drug name manually. DePiep (talk) 19:21, 1 April 2023 (UTC)
- Given the ability to download e.g. a CSV of the data, it seems mappings exist in the database. But the NDA key is probably of limited utility, because it'll rarely be appropriate for an article unless that article is about a specific company's formulation. And because this is using a trade name, it doesn't conform to the ontology for Wikipedia pages, which redirects all tracked trade names to an article about the generic drug. – Spida-tarbell (talk) 20:17, 1 April 2023 (UTC)
- 1. In the result page for trade name, I see a link that says "similar active ingredients". (ie, manual action by reader required. ouch).
- 2. 137 CSVs found. No NDAs though.
- 3. So far: if we can't find a right "FDA licence sourcepage" (INN/activesubstance is best), we must remove the datarow altogether. DePiep (talk) 20:56, 1 April 2023 (UTC)
- Given the ability to download e.g. a CSV of the data, it seems mappings exist in the database. But the NDA key is probably of limited utility, because it'll rarely be appropriate for an article unless that article is about a specific company's formulation. And because this is using a trade name, it doesn't conform to the ontology for Wikipedia pages, which redirects all tracked trade names to an article about the generic drug. – Spida-tarbell (talk) 20:17, 1 April 2023 (UTC)
- Whyw is not reproaching you for not searching ;-) they are correctly noting earlier, fruitless talks. Meanwhile, I hope we can make it work this time, see #Infobox drug FDA link below. Still, their site is hard to analyse. Which data do we expect? DePiep (talk) 17:53, 23 March 2023 (UTC)
- I see now, thanks. I apologize for not having searched through archives first! For an ongoing problem, would it still make sense to make a new topic, but additionally link to relevant archives for reference? I'm fairly new to editing, and I appreciate the time you spent here. Spida-tarbell (talk) 17:21, 23 March 2023 (UTC)
Infobox drug FDA link
- So, we need the url for the FDA drug licence source/page, as to be used in {{Infobox drug}}.
overview
- enwiki: FDA WD: Food and Drug Administration (Q204711)
- IB: {{Infobox drug}} TPU;
|legal_US=
: 2250/7900 instances
FDA databases & sitelinks (discussion)
|
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1. [1] Acronyms and Abbreviations Search 2. REMS [2] Approved Risk Evaluation and Mitigation Strategies 3. BMIS [3] Bioresearch Monitoring Information System (BMIS) 4. CLIL [4] Clinical Investigator Inspection List (CLIIL) 5. Dissolution Methods Database Search 6. Drug Establishments Current Registration Site Search 7. SrLC [5] Drug Safety-related Labeling Changes (SrLC) 8. Drug Shortages 9. [6] Drugs@FDA Search * Drugs@FDA includes information about drugs, including biological products, approved for human use in the United States (see FAQ), but does not include information about FDA-approved products regulated by the Center for Biologics Evaluation and Research (for example, vaccines, allergenic products, blood and blood products, plasma derivatives, cellular and gene therapy products). For prescription brand-name drugs, Drugs@FDA typically includes the most recent labeling approved by the FDA (for example, Prescribing Information and FDA-approved patient labeling when available), regulatory information, and FDA staff reviews that evaluate the safety and effectiveness of the drug.
10. FAERSFDA Adverse Event Reporting System (FAERS) Quarterly Data Files
11. FAERS [7] FDA Adverse Event Reporting System (FAERS) Public Dashboard 12. Inactive Ingredient Search for Approved Drug Products Search 14. National Drug Code Directory Search 15. Orange Book [8] (Approved Drug Products with Therapeutic Equivalence Evaluations) Search 16. OMUF [9] OTC Monographs@FDA 17. Outsourcing Facility Product Report 18. Postmarket Requirements and Commitments Search 19. PEPFAR President's Emergency Plan for AIDS Relief (PEPFAR) Database 20. Product-Specific Guidances for Generic Drug Development Database 21. Purple Book [10] (database of FDA-licensed (approved) biological products, including biosimilar and interchangeable products) 22. Wholesale Distributor and Third-Party Logistics Providers Reporting |
pilots & demos (aspirin, ..)
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- database .. (pls expand useful database info)
- Key (some drug id? expected): .. WD: ..
- Drugs@FDA: FDA-Approved Drugs
- OpenFDA d:WDQS Query Helper (Q22907487) https://open.fda.gov/
- wikidata: d:Template:Medical_properties
proposals & discuss
In general, Wikidata has good url formatter for such a database. -DePiep (talk) 07:07, 23 March 2023 (UTC)
- Which FDA data should we linkto in the infobox? Which is preferable in the article? -DePiep (talk) 07:44, 23 March 2023 (UTC)
- One test we must make is which key(s) FDA uses.
- INN
- USAN United States Adopted Name (acetaminophen)
- USP United States Pharmacopeia (acetaminophen)
- private key (=FDA-maintained; published we hope)
- marketet name
- -DePiep (talk) 15:28, 23 March 2023 (UTC)
- It could be helpful to make a quickl & crude improvement first. (workin url to an FDA overview). -DePiep (talk) 15:28, 23 March 2023 (UTC)
- Approved drug FDA-page is needed (for 'FDA-licence').
- Special licences lists:
- Orange book (en:[Orange book]) = "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations"
- Purple book = "Database of Licensed Biological Products"
Bispecific monoclonal antibody
Please add BsAb
as a mab type for a bispecific monoclonal antibody. --Whywhenwhohow (talk) 04:20, 25 April 2023 (UTC)
- OK, working on this. Please see testcases4#BsAb (new). Some questions:
- Per the article, I understand BsMAb is a synonym. Accept as option? (is already in /sandbox).
- Does BsAb have new
|source=
options to add? - What would be a
|target=
example?, and drug demo article? DePiep (talk) 08:18, 25 April 2023 (UTC) - Also, when
|type=mab
, are these two parameters required? Or can one be empty?|mab_type=
,|source=
- (see their options at mab type /doc tables). -DePiep (talk) 15:00, 25 April 2023 (UTC)
- In my experience, BsAb appears to be more common than BsMAb. Examples of BsAbs include amivantamab, emicizumab, and glofitamab.
- Some BsAbs use the BiTE plaform and are Bi-specific T-cell engagers (e.g. blinatumomab, mosunetuzumab, teclistamab). The BiTE mab_type is supported in the template.
- There is also a trAb (trifunctional antibody) type (e.g. catumaxomab, ertumaxomab) that appears to be supported in the template as mab_type 3funct.
- Thanks and hope this is helpful. --Whywhenwhohow (talk) 05:30, 26 April 2023 (UTC)
- Thanks, towards implementation.
- Btw, tracking in Category:Infobox drug articles with an unformatted antibody source (0) will be expanded to: "
|type=mab
OK but|mab_type or source=
not recognised/blank". DePiep (talk) 06:10, 26 April 2023 (UTC)
Tolerance potential?
I’m sort of puzzled why things like addiction liability and dependence liability are a thing in these info boxes for various drugs but tolerance potential/rate isn’t? I know there is a number of variables like dosage and rate of frequency and even individual enzyme properties, or maybe even receptor sensitivity, but the same is also evidently true for the other aforementioned potentials. From what I can clearly tell, some substances certainly have abnormally fast tolerance increases (such as opioids & amphetamines); whereas others can have pretty modest rate of increased tolerance. And even substances with potential for reverse-tolerance (like salvia and cannabis) should also have this mentioned in the infobox. Dexedream (talk) 04:36, 10 May 2023 (UTC)
Legal status in Brazil - Add subclasses F1, F2 and F3
Keep the "Class F (Prohibited substances)" for backward compatibility, but add:
- Class F1 (Prohibited narcotics)
- Class F2 (Prohibited psychotropics)
- Class F3 (Prohibited precursors)
- Class F4 (Other prohibited substances)
There is also a specific list for antibiotics, but I'm thinking to just use the general "Rx-only" tag for that. I need to dig, search for more information and think how that could be classified here. But for now, just adding the F subclasses would be great. Thanks :) Arthurfragoso (talk) 20:12, 3 August 2023 (UTC)
- I would like the changes shown in this diff. — Arthurfragoso (talk) 17:41, 27 August 2023 (UTC)
- Completed. P.I. Ellsworth , ed. put'er there 23:52, 27 August 2023 (UTC)
Edit request 5 August 2023
Description of suggested change:
Template:Infobox_drug/formatIUPHARBPS should use https
instead of http
.
- Completed. P.I. Ellsworth , ed. put'er there 20:15, 5 August 2023 (UTC)
Adding new countries to Legal Status
The main ones I would like to be added are: India, China and Russia. But clicking in the Category:Drugs with non-standard legal status and checking some, we may have to add South Korea (Olmutinib), Singapore(5-Benzyloxytryptamine), Sweden (Flualprazolam) and Japan (Delgocitinib, Tirabrutinib) at some point. Mexico would be another good one to add. Or we could just add the whole ISO 639-1 list of country codes. 😅
- Drug policy of India -> But the categories listed at Regulation of therapeutic goods#India (Schedule X, H, L, C, C1, N, M) - I found the Indian government document explaining each one the other day, I believe there is more categories than this, I will find it again and make a summary.
- Drug policy of South Korea - Not much explanation, but we could initially just add the general OTC, Rx, vet.
- Drug policy of Sweden - Schedule I to V
- Misuse of Drugs Act (Singapore) - Schedule I to III and subcategories
The easiest information available about Chinese drug regulation is the "OTC class A" (drugstores only) and "OTC class B" (also available in general stores).
It's too much to add information about the classification about each countries at once. I'm initially informing the intent, but I will dig and summarize about each one in more details later.
-- Arthurfragoso (talk) 21:17, 14 August 2023 (UTC)
- All the schedules in India are at: Drugs and Cosmetics Rules, 1945
- -- Arthurfragoso (talk) 05:59, 15 August 2023 (UTC)
Template-protected edit request on 3 September 2023
The link to EMA pages is dead, and should most likely be replaced as follows;
From
EU EMA -->{{#ifeq:{{{licence_EU|}}} |yes| * <small>{{abbr|EU|European Union|class=country-name}}</small> [[European Medicines Agency|EMA]]: <span title="www.ema.europa.eu: '{{#invoke:String|replace|source={{{_EMA_use_INN|}}} |pattern=[%<%>]|replace=|plain=false}}' ">[http://www.ema.europa.eu/ema/index.jsp?curl=%2Fpages%2Fmedicines%2Flanding%2Fepar_search.jsp&mid=&searchTab=searchByKey&alreadyLoaded=true&isNewQuery=true&status=Authorised&status=Withdrawn&status=Suspended&status=Refused&keywordSearch=Submit&searchType=inn&taxonomyPath=&treeNumber=&searchGenericType=generics&keyword={{urlencode:{{#invoke:String|replace|source={{{_EMA_use_INN|}}} |pattern=(%w)%/(%w)|replace=%1 / %2|plain=false}} }} {{#if:{{{INN_EMA|}}} |by {{{INN_EMA|}}} |by INN}}]</span> }}<!--
To
EU EMA -->{{#ifeq:{{{licence_EU|}}} |yes| * <small>{{abbr|EU|European Union|class=country-name}}</small> [[European Medicines Agency|EMA]]: <span title="www.ema.europa.eu: '{{#invoke:String|replace|source={{{_EMA_use_INN|}}} |pattern=[%<%>]|replace=|plain=false}}' ">[https://www.ema.europa.eu/en/medicines/search_api_aggregation_ema_active_substance_and_inn_common_name/{{urlencode:{{#invoke:String|replace|source={{{_EMA_use_INN|}}} |pattern=(%w)%/(%w)|replace=%1 / %2|plain=false}} }} {{#if:{{{INN_EMA|}}} |by {{{INN_EMA|}}} |by INN}}]</span> }}<!--
This should ensure proper link references working, for EMA approvals. 62.83.128.242 (talk) 02:04, 3 September 2023 (UTC)
- Done For the record, the new links often don't work for me either, but they sometimes do and it's clearly better than the old completely-broken ones. * Pppery * it has begun... 21:42, 4 September 2023 (UTC)
Global Substance Registration System - GSRS
Please consider adding GSRS to the infobox.
The Global Ingredient Archival System provides a common identifier for all of the substances used in medicinal products, utilizing a consistent definition of substances globally, including active substances under clinical investigation, consistent with the ISO 11238 standard.
--Whywhenwhohow (talk) 18:00, 24 September 2023 (UTC)