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'''Pseudoginsenoside F11''' is a chemical [[natural product]] found in [[American ginseng]] (''Panax quinquefolius'') but not in [[ginseng|Asian ginseng]] (''Panax ginseng''), although it has similar properties to the Asian ginseng compound [[ginsenoside|ginsenoside Rf]]. <ref name="phytoreview">{{cite journal|last1=Qi|first1=LW|last2=Wang|first2=CZ|last3=Yuan|first3=CS|title=Ginsenosides from American ginseng: chemical and pharmacological diversity.|journal=Phytochemistry|date=June 2011|volume=72|issue=8|pages=689-99|pmid=21396670}}</ref> The molecule is a [[triterpenoid saponin]] member of the [[dammarane]] family and contains a four-[[polycyclic compound|ring]] rigid skeleton.<ref name="phytoreview" /> Compounds in the ginsenoside family are found almost exclusively in plants of the ''Panax'' genus, which have long histories of use in [[traditional medicine]]; a wide variety of difficult-to-characterize biological effects have been reported for the compounds in isolation.<ref>{{cite journal|last1=Attele|first1=AS|last2=Wu|first2=JA|last3=Yuan|first3=CS|title=Ginseng pharmacology: multiple constituents and multiple actions.|journal=Biochemical pharmacology|date=1 December 1999|volume=58|issue=11|pages=1685-93|pmid=10571242}}</ref><ref>{{cite journal|last1=Christensen|first1=LP|title=Ginsenosides chemistry, biosynthesis, analysis, and potential health effects.|journal=Advances in food and nutrition research|date=2009|volume=55|pages=1-99|pmid=18772102}}</ref> Pseudoginsenoside F11 and its derivatives are sometimes referred to as having an ''ocotillol''-type skeleton structure.<ref name="phytoreview" /><ref>{{cite journal|last1=Fuzzati|first1=N|title=Analysis methods of ginsenosides.|journal=Journal of chromatography. B, Analytical technologies in the biomedical and life sciences|date=5 December 2004|volume=812|issue=1-2|pages=119-33|pmid=15556492}}</ref> |
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'''Pseudoginsenoside F11'''is effective in protection from [[methamphetamine]]-induced neurotoxicity. It might be a potential candidate for the prevention and treatment of the neurological disorders induced by methamphetamine abuse.<ref>http://www.sciencedirect.com/science/article/pii/S0091305703002156</ref> |
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Studies in [[laboratory mouse|mice]] have identified [[antagonist (pharmacology)|antagonistic]] effects on the actions of other well-characterized drugs, such as [[scopolamine]] (which in mice impairs memory),<ref>{{cite journal|last1=Li|first1=Z|last2=Guo|first2=YY|last3=Wu|first3=CF|last4=Li|first4=X|last5=Wang|first5=JH|title=Protective effects of pseudoginsenoside-F11 on scopolamine-induced memory impairment in mice and rats.|journal=The Journal of pharmacy and pharmacology|date=April 1999|volume=51|issue=4|pages=435-40|pmid=10385216}}</ref> [[morphine]],<ref>{{cite journal|last1=Li|first1=Z|last2=Wu|first2=CF|last3=Pei|first3=G|last4=Guo|first4=YY|last5=Li|first5=X|title=Antagonistic effect of pseudoginsenoside-F11 on the behavioral actions of morphine in mice.|journal=Pharmacology, biochemistry, and behavior|date=July 2000|volume=66|issue=3|pages=595-601|pmid=10899376}}</ref><ref>{{cite journal|last1=Hao|first1=Y|last2=Yang|first2=JY|last3=Wu|first3=CF|last4=Wu|first4=MF|title=Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice.|journal=Pharmacology, biochemistry, and behavior|date=April 2007|volume=86|issue=4|pages=660-6|pmid=17368734}}</ref> and [[methamphetamine]].<ref>{{cite journal|last1=Wu|first1=CF|last2=Liu|first2=YL|last3=Song|first3=M|last4=Liu|first4=W|last5=Wang|first5=JH|last6=Li|first6=X|last7=Yang|first7=JY|title=Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice.|journal=Pharmacology, biochemistry, and behavior|date=August 2003|volume=76|issue=1|pages=103-9|pmid=13679222}}</ref> |
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==References== |
==References== |
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{{Reflist}} |
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[http://www.chemnorm.com/Product/Pseudoginsenoside%20F11-TP027175.html Pseudoginsenoside F11 on ChemNorm] |
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[[Category:Terpenes and terpenoids]] |
Revision as of 07:03, 18 March 2015
Pseudoginsenoside F11 is a chemical natural product found in American ginseng (Panax quinquefolius) but not in Asian ginseng (Panax ginseng), although it has similar properties to the Asian ginseng compound ginsenoside Rf. [1] The molecule is a triterpenoid saponin member of the dammarane family and contains a four-ring rigid skeleton.[1] Compounds in the ginsenoside family are found almost exclusively in plants of the Panax genus, which have long histories of use in traditional medicine; a wide variety of difficult-to-characterize biological effects have been reported for the compounds in isolation.[2][3] Pseudoginsenoside F11 and its derivatives are sometimes referred to as having an ocotillol-type skeleton structure.[1][4]
Studies in mice have identified antagonistic effects on the actions of other well-characterized drugs, such as scopolamine (which in mice impairs memory),[5] morphine,[6][7] and methamphetamine.[8]
References
- ^ a b c Qi, LW; Wang, CZ; Yuan, CS (June 2011). "Ginsenosides from American ginseng: chemical and pharmacological diversity". Phytochemistry. 72 (8): 689–99. PMID 21396670.
- ^ Attele, AS; Wu, JA; Yuan, CS (1 December 1999). "Ginseng pharmacology: multiple constituents and multiple actions". Biochemical pharmacology. 58 (11): 1685–93. PMID 10571242.
- ^ Christensen, LP (2009). "Ginsenosides chemistry, biosynthesis, analysis, and potential health effects". Advances in food and nutrition research. 55: 1–99. PMID 18772102.
- ^ Fuzzati, N (5 December 2004). "Analysis methods of ginsenosides". Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 812 (1–2): 119–33. PMID 15556492.
- ^ Li, Z; Guo, YY; Wu, CF; Li, X; Wang, JH (April 1999). "Protective effects of pseudoginsenoside-F11 on scopolamine-induced memory impairment in mice and rats". The Journal of pharmacy and pharmacology. 51 (4): 435–40. PMID 10385216.
- ^ Li, Z; Wu, CF; Pei, G; Guo, YY; Li, X (July 2000). "Antagonistic effect of pseudoginsenoside-F11 on the behavioral actions of morphine in mice". Pharmacology, biochemistry, and behavior. 66 (3): 595–601. PMID 10899376.
- ^ Hao, Y; Yang, JY; Wu, CF; Wu, MF (April 2007). "Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice". Pharmacology, biochemistry, and behavior. 86 (4): 660–6. PMID 17368734.
- ^ Wu, CF; Liu, YL; Song, M; Liu, W; Wang, JH; Li, X; Yang, JY (August 2003). "Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice". Pharmacology, biochemistry, and behavior. 76 (1): 103–9. PMID 13679222.