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'''Hexylcaine hydrochloride''', also called '''cyclaine''' ([[Merck & Co.|Merck]]) or '''osmocaine''', is a short-acting [[local anesthetic]]. It acts by inhibiting [[sodium channel]] conduction. Overdose can lead to [[headache]], [[tinnitus]], [[paresthesia|numbness and tingling]] around the mouth and tongue, [[convulsion]]s, [[respiratory arrest|inability to breathe]], and decreased heart function.<ref name="pmid13620024">{{cite journal | vauthors = Spellberg MA | title = Hexylcaine (cyclaine) as topical anesthetic in gastroscopy and esophagoscopy | journal = Gastroenterology | volume = 36 | issue = 1 | pages = 120–1 | date = January 1959 | pmid = 13620024 | doi = 10.1016/S0016-5085(59)80102-5| url = }}</ref> |
'''Hexylcaine hydrochloride''', also called '''cyclaine''' ([[Merck & Co.|Merck]]) or '''osmocaine''', is a short-acting [[local anesthetic]]. It acts by inhibiting [[sodium channel]] conduction. Overdose can lead to [[headache]], [[tinnitus]], [[paresthesia|numbness and tingling]] around the mouth and tongue, [[convulsion]]s, [[respiratory arrest|inability to breathe]], and decreased heart function.<ref name="pmid13620024">{{cite journal | vauthors = Spellberg MA | title = Hexylcaine (cyclaine) as topical anesthetic in gastroscopy and esophagoscopy | journal = Gastroenterology | volume = 36 | issue = 1 | pages = 120–1 | date = January 1959 | pmid = 13620024 | doi = 10.1016/S0016-5085(59)80102-5| url = }}</ref> |
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==Synthesis== |
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[[File:Hexylcaine synthesis.svg|thumb|center|500px|Synthesis:<ref>Cope, Arthur C.; Hancock, Evelyn M. (1944). "1-Alkylamino-2-propanols and their p-Nitro- and p-Aminobenzoates". Journal of the American Chemical Society 66 (9): 1453–1456. doi:10.1021/ja01237a010.</ref><ref>"Local Anesthetics". New England Journal of Medicine. 263 (19): 963–965.1960. doi:10.1056/NEJM196011102631912. </ref> Patent:<ref>Cope Arthur C, US2486374 (1949 to Sharp & Dohme Inc).</ref>]] |
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==References== |
==References== |
Revision as of 10:46, 25 October 2022
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Elimination half-life | <10 minutes |
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Formula | C16H23NO2 |
Molar mass | 261.365 g·mol−1 |
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Hexylcaine hydrochloride, also called cyclaine (Merck) or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.[1]
Synthesis
References
- ^ Spellberg MA (January 1959). "Hexylcaine (cyclaine) as topical anesthetic in gastroscopy and esophagoscopy". Gastroenterology. 36 (1): 120–1. doi:10.1016/S0016-5085(59)80102-5. PMID 13620024.
- ^ Cope, Arthur C.; Hancock, Evelyn M. (1944). "1-Alkylamino-2-propanols and their p-Nitro- and p-Aminobenzoates". Journal of the American Chemical Society 66 (9): 1453–1456. doi:10.1021/ja01237a010.
- ^ "Local Anesthetics". New England Journal of Medicine. 263 (19): 963–965.1960. doi:10.1056/NEJM196011102631912.
- ^ Cope Arthur C, US2486374 (1949 to Sharp & Dohme Inc).