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'''Floxuridine''' is an [[oncology]] drug that belongs to the class known as [[antimetabolite]]s. The drug is most often used in the treatment of colorectal cancer. |
'''Floxuridine''' (also ''5-fluorodeoxyuridine'') is an [[oncology]] drug that belongs to the class known as [[antimetabolite]]s. The drug is most often used in the treatment of colorectal cancer. |
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==Pharmacology== |
==Pharmacology== |
Revision as of 19:42, 8 November 2011
Clinical data | |
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AHFS/Drugs.com | Monograph |
MedlinePlus | a682006 |
ATC code |
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DrugBank | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.066 |
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Formula | C9H11FN2O5 |
Molar mass | 246.192 g/mol g·mol−1 |
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Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.
Pharmacology
Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine.
Mechanism of action
Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.
History
Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to F H Faulding, which became Mayne Pharma.
Suppliers
In the US the drug is supplied by APP Pharmaceuticals, LLC; Hospira, Inc.; and Bedford Laboratories.
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.