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'''Estramustine''' ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}, {{abbrlink|BAN|British Approved Name}}) is a [[synthetic compound|synthetic]], [[steroid]]al [[estrogen (medication)|estrogen]] and [[cytostatic]] [[antineoplastic agent]] which was never marketed.<ref name="Elks2014">{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA502|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=502–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA406|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=406–}}</ref> It is an [[estrogen ester]] – specifically, the C3 [[normustine]] [[ester]] of [[estradiol]] – and acts in part as a [[prodrug]] of estradiol in the body.<ref name="Elks2014" /><ref name="IndexNominum2000" /> [[Estramustine phosphate]], the C17β [[phosphate]] [[ester]] of estramustine, is marketed and used in the treatment of [[prostate cancer]].<ref name="Elks2014" /><ref name="IndexNominum2000" /> |
'''Estramustine''' ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}, {{abbrlink|BAN|British Approved Name}}) is a [[synthetic compound|synthetic]], [[steroid]]al [[estrogen (medication)|estrogen]] and [[cytostatic]] [[antineoplastic agent]] which was never marketed.<ref name="Elks2014">{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA502|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=502–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA406|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=406–}}</ref> It is an [[estrogen ester]] – specifically, the C3 [[normustine]] [[ester]] of [[estradiol (medication)|estradiol]] – and acts in part as a [[prodrug]] of estradiol in the body.<ref name="Elks2014" /><ref name="IndexNominum2000" /> [[Estramustine phosphate]], the C17β [[phosphate]] [[ester]] of estramustine, is marketed and used in the treatment of [[prostate cancer]].<ref name="Elks2014" /><ref name="IndexNominum2000" /> |
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==See also== |
==See also== |
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* [[List of hormonal |
* [[List of hormonal cytostatic antineoplastic agents]] |
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* [[List of estrogen esters#Estradiol esters|List of estrogen esters § Estradiol esters]] |
* [[List of estrogen esters#Estradiol esters|List of estrogen esters § Estradiol esters]] |
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[[Category:Abandoned drugs]] |
[[Category:Abandoned drugs]] |
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[[Category:Antigonadotropins]] |
[[Category:Antigonadotropins]] |
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[[Category:Antineoplastic |
[[Category:Antineoplastic drugs]] |
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[[Category:Carbamates]] |
[[Category:Carbamates]] |
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[[Category:Estradiol esters]] |
[[Category:Estradiol esters]] |
Revision as of 09:07, 21 September 2018
Clinical data | |
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Other names | EM; EaM; Leo 275; Ro 21-8837; Estradiol 3-(bis(2-chloroethyl)carbamate) ester; Estra-1,3,5(10)-triene-3,17β-diol 3-(bis(2-chloroethyl)carbamate) ester |
Drug class | Nitrogen mustard; Alkylating antineoplastic agent; Estrogen; Estrogen ester |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.019.161 |
Chemical and physical data | |
Formula | C23H31Cl2NO3 |
Molar mass | 440.405 g/mol g·mol−1 |
3D model (JSmol) | |
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(what is this?) |
Estramustine (INN , USAN , BAN ) is a synthetic, steroidal estrogen and cytostatic antineoplastic agent which was never marketed.[1][2] It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts in part as a prodrug of estradiol in the body.[1][2] Estramustine phosphate, the C17β phosphate ester of estramustine, is marketed and used in the treatment of prostate cancer.[1][2]
See also
References
- ^ a b c J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 502–. ISBN 978-1-4757-2085-3.
- ^ a b c Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 406–. ISBN 978-3-88763-075-1.