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| verifiedrevid = |
| verifiedrevid = 426033441 |
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| IUPAC_name = (2''Z'',4''E'',6''E'',12''E'')-16,20-dihydroxy-21-methoxy-<br>3-methyl-10-phenyl-9-azabicyclo[17.3.0]<br>docosa-2,4,6,12,19-pentaene-8,18-dione |
| IUPAC_name = (2''Z'',4''E'',6''E'',12''E'')-16,20-dihydroxy-21-methoxy-<br>3-methyl-10-phenyl-9-azabicyclo[17.3.0]<br>docosa-2,4,6,12,19-pentaene-8,18-dione |
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| image = Hitachimycin.svg |
| image = Hitachimycin.svg |
Revision as of 21:14, 30 August 2011
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Formula | C29H35NO5 |
Molar mass | 477.592 g/mol g·mol−1 |
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Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as an antitumor antibiotic.[2]
As of 2007, it has not been used in a clinical setting.
References
- ^ Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301–11. PMID 6833150.
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: CS1 maint: multiple names: authors list (link) - ^ Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259–65. PMID 7275806.
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: CS1 maint: multiple names: authors list (link)