Updating {{drugbox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report errors or [[u |
populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBot |
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{{Unreferenced|date=December 2009}} |
{{Unreferenced|date=December 2009}} |
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{{Drugbox |
{{Drugbox |
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| verifiedrevid = 443820414 |
| verifiedrevid = 443820414 |
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| IUPAC_name = 5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione |
| IUPAC_name = 5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione |
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| image = Floxuridine.png |
| image = Floxuridine.png |
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<!--Clinical data--> |
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| tradename = |
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| Drugs.com = {{drugs.com|monograph|floxuridine}} |
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| MedlinePlus = a682006 |
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<!--Pharmacokinetic data--> |
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<!--Identifiers--> |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 5586 |
| ChemSpiderID = 5586 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 039LU44I5M |
| UNII = 039LU44I5M |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 917 |
| ChEMBL = 917 |
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<!--Chemical data--> |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
| StdInChI = 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
| StdInChIKey = ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
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}} |
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'''Floxuridine''' is an [[oncology]] drug that belongs to the class known as [[antimetabolite]]s. The drug is most often used in the treatment of colorectal cancer. |
'''Floxuridine''' is an [[oncology]] drug that belongs to the class known as [[antimetabolite]]s. The drug is most often used in the treatment of colorectal cancer. |
Revision as of 07:59, 30 August 2011
Clinical data | |
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AHFS/Drugs.com | Monograph |
MedlinePlus | a682006 |
ATC code |
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Legal status | |
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Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.066 |
Chemical and physical data | |
Formula | C9H11FN2O5 |
Molar mass | 246.192 g/mol g·mol−1 |
3D model (JSmol) | |
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(verify) |
Floxuridine is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.
Pharmacology
Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine.
Mechanism of action
Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.
History
Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to F H Faulding, which became Mayne Pharma.
Suppliers
In the US the drug is supplied by APP Pharmaceuticals, LLC; Hospira, Inc.; and Bedford Laboratories.
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.