populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBot |
Updating {{drugbox}} (changes to verified and watched fields - updated 'KEGG_Ref') per Chem/Drugbox validation (report errors or [[user talk:CheMoBot|b |
||
Line 22: | Line 22: | ||
| UNII_Ref = {{fdacite|correct|FDA}} |
| UNII_Ref = {{fdacite|correct|FDA}} |
||
| UNII = SUG9176GRW |
| UNII = SUG9176GRW |
||
| KEGG_Ref = {{keggcite|changed|kegg}} |
|||
| KEGG = D05587 |
| KEGG = D05587 |
||
| ChEBI_Ref = {{ebicite|changed|EBI}} |
| ChEBI_Ref = {{ebicite|changed|EBI}} |
Revision as of 05:37, 30 August 2011
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 417937543 | IUPAC_name = (RS)-N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide | image = Practolol.png
| tradename =
| CASNo_Ref = | CAS_number = 6673-35-4 | ATC_prefix = C07 | ATC_suffix = AB01 | PubChem = 4883 | IUPHAR_ligand = 555 | DrugBank_Ref = | DrugBank = DB01297 | ChemSpiderID_Ref = | ChemSpiderID = 4715 | UNII_Ref = | UNII = SUG9176GRW | KEGG_Ref = | KEGG = D05587 | ChEBI_Ref = | ChEBI = 258351 | ChEMBL_Ref = | ChEMBL = 6995
| C=14 | H=22 | N=2 | O=3 | molecular_weight = 266.336 g/mol | smiles = O=C(Nc1ccc(OCC(O)CNC(C)C)cc1)C | InChI = 1/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17) | InChIKey = DURULFYMVIFBIR-UHFFFAOYAT | StdInChI_Ref = | StdInChI = 1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17) | StdInChIKey_Ref = | StdInChIKey = DURULFYMVIFBIR-UHFFFAOYSA-N }}
Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) is a selective beta blocker that has been used in the emergency treatment of cardiac arrhythmias. Practolol is no longer used as it is highly toxic despite the similarity of its chemical formula to propanolol. The use of practolol has been referred to as the practolol disaster and is considered the worst medical blunders since thalidomide.
Side effects
Side effects are similar to those of other beta blockers, such as bronchoconstriction, cardiac failure, cold extremities, fatigue and depression, hypoglycaemia.[1]
Furthermore, chronic use of practolol may cause oculomucocutaneous syndrome,[1] a severe syndrome whose signs include conjunctivitis sicca and psoriasiform rashes, otitis and sclerosing serositis. This syndrome has not been observed with other such beta blockers.[2]
References
External links
- Scientific information / studies
- Guinea Pig study from 1975
- Liver effect study from 1981
- Study of uses during surgery
- Molecular structure
- General information