Zambezia may refer to:
- Zambesia, a self-proclaimed state in Southern Africa.
- Zambezia Province, Mozambique
- Zambezia, Cabo Delgado, Mozambique
- Zambezia (film), a 2012 South African animated film
- Zambezia (journal): The Journal of Humanities of the University of Zimbabwe
- Zambezia or Zambesia, an early name for Rhodesia (now Zambia and Zimbabwe)