Protein-coding gene in the species Homo sapiens
TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene .[ 5] [ 6] [ 7]
Function
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.[ 6] [ 7]
Interactions
TNIK has been shown to interact with KIAA0090 ,[ 8] although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin , a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes.[ 6]
TNIK plays an important role in pulmonary fibrosis . Inhibitors of TNIK are used in the treatment of pulmonary fibrosis. [ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000154310 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027692 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (1): 31–9. doi :10.1093/dnares/5.1.31 . PMID 9628581 .
^ a b c Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton" . J Biol Chem . 274 (43): 30729–37. doi :10.1074/jbc.274.43.30729 . PMID 10521462 .
^ a b "Entrez Gene: TNIK TRAF2 and NCK interacting kinase" .
^ Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer" . Nucleic Acids Res . 34 (Web Server issue): W298–302. doi :10.1093/nar/gkl128 . PMC 1538863 . PMID 16845013 . Archived from the original on 2010-04-09.
^ Garneau-Tsodikova, Sylvie; Thannickal, Victor J. (2008). "Protein kinase inhibitors in the treatment of pulmonary fibrosis" . Current Medicinal Chemistry . 15 (25): 2632–2640. doi :10.2174/092986708785908969 . ISSN 0929-8673 . PMID 18855683 .
Further reading
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones" . DNA Res . 9 (3): 99–106. doi :10.1093/dnares/9.3.99 . PMID 12168954 .
Yonekura H, Migita H, Sakurai S, et al. (1999). "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes" . Nucleic Acids Res . 27 (13): 2591–600. doi :10.1093/nar/27.13.2591 . PMC 148466 . PMID 10373574 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem . 76 (10): 2763–72. doi :10.1021/ac035352d . PMID 15144186 .
Taira K, Umikawa M, Takei K, et al. (2005). "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton" . J. Biol. Chem . 279 (47): 49488–96. doi :10.1074/jbc.M406370200 . PMID 15342639 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" . Mol. Cell. Proteomics . 6 (3): 537–47. doi :10.1074/mcp.T600062-MCP200 . hdl :10033/19756 . PMID 17192257 .