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== About me: == |
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'''Methcathinone''' is a [[recreational drug]] that is cheap and simple to [[synthesize]]. It is usually snorted, but can be smoked, injected, or taken orally. Methcathinone is currently a [[Drug Enforcement Administration|DEA]] Schedule I chemical. |
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I live in [[Brisbane]] ''[[Queensland]]'' '''[[Australia]]'''. |
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My hobbies are : |
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{| border="1" cellpadding="3" cellspacing="0" align="right" width="250px" style="border-collapse: collapse; margin: 0 0 0 0.5em" |
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* Going to movies |
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|- |
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* Family history |
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| bgcolor="#ffffff" align="center" colspan="2" | |
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* Learning [[French language|French]] |
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[[Image:Methcathinone_2D_Structure.gif|240px|Methcathinone chemical structure]]<br/> |
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* Watch [[ABC (Australian TV channel)|ABC]] and [[SBS (Australian TV channel)|SBS]] |
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''Methcathinone'' |
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|- |
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| align="center" colspan="2" | [[IUPAC nomenclature|IUPAC]] name: <br /> |
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''2-(methylamino)-I-phenyl-propan-1-one'' |
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|- align="center" style="border-bottom: 3px solid gray" |
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| '''[[CAS number]]''' <br/> 5650-44-2 |
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| '''[[ATC code]]''' <br/> ? |
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|- |
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| bgcolor="#eeeeee" | [[Chemical formula]] |
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| bgcolor="#ddeeff" | [[Carbon|C]]<sub>10</sub>[[Hydrogen|H]]<sub>13</sub>[[Nitrogen|N]][[Oxygen|O]] |
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|- |
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| bgcolor="#eeeeee" | [[Molecular weight]] |
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| bgcolor="#ddeeff" | 163.22 |
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|- |
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| bgcolor="#eeeeee" | [[Bioavailability]] |
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| bgcolor="#ddeeff" | ? |
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|- |
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| bgcolor="#eeeeee" | Metabolism |
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| bgcolor="#ddeeff" | ? |
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|- |
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| bgcolor="#eeeeee" | [[half life|Elimination half life]] |
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| bgcolor="#ddeeff" | ? |
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|- |
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| bgcolor="#eeeeee" | [[Excretion]] |
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| bgcolor="#ddeeff" | [[Urine]] |
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|- |
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| bgcolor="#eeeeee" | [[Pregnancy category (pharmaceutical)|Pregnancy category]] |
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| bgcolor="#ddeeff" | ? |
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|- |
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| bgcolor="#eeeeee" | [[Controlled Substance Act|Legal status]] |
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| bgcolor="#ddeeff" | Schedule I ([[USA]]) |
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|- |
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| bgcolor="#eeeeee" | Delivery |
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| bgcolor="#ddeeff" | [[Vaporize|Vaporized]], [[Insufflate|Insufflated]], [[Intravenous infusion|Injected]], Taken Orally |
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|- |
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</table><table bgcolor="#ffffff" border="1" cellpadding="3" cellspacing="0" align="right" width="167px" style="border-collapse: collapse; clear: right; margin: 0 0 0 0.5em"> |
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|- |
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|'''Indicated for:'''<br/> |
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*? |
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== Fascinating facts that I know: == |
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'''[[Recreational drug use|Recreational]] uses:'''<br/> |
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[[Malcolm Turnbull]] is [[Prime minister|Prime Minister]] of [[Australia]]<ref>{{Cite web|url=https://www.pm.gov.au/|title=Prime Minister of Australia|last=|first=|date=|website=|publisher=Australian Government|archive-url=|archive-date=|dead-url=|access-date=24 March 2017}}</ref> |
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*[[Euphoria]] |
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*[[Amphetamine|Speed]] |
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== References: == |
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'''[[Ethics|Unethical]] uses:'''<br/> |
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<references /> |
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*? |
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'''Other uses:'''<br/> |
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*? |
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|- |
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|'''[[Contraindication]]s:'''<br/> |
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*? |
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|- |
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|'''[[Side effect]]s:''' |
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<div style="background: #ffcc99"> |
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'''''{{red|Severe:}}''''' |
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*? |
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</div> |
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'''''Atypical [[sensation]]s:''''' |
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*? |
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'''''[[Cardiovascular]]:''''' |
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*? |
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'''''[[Ear]], [[nose]], and [[throat]]:''''' |
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*? |
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'''''[[Endocrinal]]:''''' |
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*? |
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'''''[[Eye]]:''''' |
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*? |
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'''''[[Gastrointestinal]]:''''' |
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*? |
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'''''[[Hematological]]:''''' |
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*? |
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'''''[[Muscle|Musculo]][[skeletal]]:''''' |
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*? |
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'''''[[Neurological]]:''''' |
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*? |
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'''''[[Psychological]]:''''' |
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*? |
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'''''[[Respiratory]]:''''' |
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*? |
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'''''[[Skin]]:''''' |
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*? |
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'''''[[Urogenital]] and [[reproductive]]:''''' |
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*? |
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'''''Miscellaneous:''''' |
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*? |
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|} |
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==History== |
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'''Methcathinone''' was first synthesized in Germany in [[1928]]. It was used in the [[Soviet Union]] during the [[1930s]] and [[1940s]] as an [[anti-depressant]]. Since the [[1960s]], methcathinone has been used as a [[recreational drug]] in the [[Soviet Union]]. |
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==Chemistry== |
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'''Methcathinone''' is very similar in structure to [[cathinone]], a [[stimulant]] [[alkaloid]] occurring in the [[shrub]] ''[[Catha edulis]]'' ([[Khat]]), the [[synthetic]] [[stimulant]] [[methamphetamine]], and other [[phenethylamine]]s. |
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Methcathinone has a single [[asymmetric]] [[carbon atom]], thus yielding [[enantiomeric]] + and - forms. [[Chemical Abstract Services]] registry numbers for the [[racemic]] [[base (chemistry)|base]] and [[hydrochloride]] forms are 5650-44-2 and 49656-78-2, respectively. The [[Chemical Abstract Services]] registry numbers for the [[base]] and [[hydrochloride]] forms of the S absolute [[stereochemical]] configuration are 112117-24-5 and 66514-93-0, respectively. |
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Various names for methcathinone include |
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* ''2-([[methyl]][[amino]])-propio[[phenone]]'' |
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* ''[[ALPHA]]-([[methyl]][[amino]])-propio[[phenone]]'' |
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* ''[[ALPHA]]-N-[[methyl]][[amino]]propio[[phenone]] '' |
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* ''2-([[methyl]][[amino]])-1-[[phenyl]]propan-1-one, mono[[methyl]]propion'' |
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* ''N-[[methyl]][[cathinone]]'' |
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* ''N-mono[[methyl]][[cathinone]]'' |
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* ''[[methyl]][[cathinone]]'' |
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* ''AL-464 (1 isomer)'' |
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* ''AL-422 (racemate)'' |
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* ''AL-463 (d-isomer)'' |
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* ''UR1431'' |
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* ''UR(W)1431'' |
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Methcathinone hydrochloride increases spontaneous rodent [[locomotor]] activity, potentiates the release of radio-labelled [[dopamine]] from [[dopaminergic]] [[nerve]] terminals in the [[brain]], and causes [[appetite suppression]]. |
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'''Methcathinone''' is most commonly made by the [[oxidation]] of [[ephedrine]]. [[Oxidation]] of [[ephedrine]] to methcathinone requires almost zero [[chemistry]] experience, making it easy to synthesize. [[Potassium permanganate]] ([[Potassium|K]][[Manganese|Mn]][[Oxygen|O]]<sub>4</sub>) is most the commonly used in the [[oxidant]]. |
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Methcathinone can also be [[synthesize|synthesized]] via the [[oxygen|oxidation]] of l-[[ephedrine]] using [[sodium dichromate]] and [[sulphuric acid]]. This process is just as simple as oxydizing the ephedrine with potassium permanganate. |
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'''Methcathinone''' acts on the body & brain much like [[methamphetamine]] & [[amphetamine do]]. |
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==Effects== |
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The effects of '''methcathinone''' are similar to those of [[methamphetamine]], but much more euphoric. The effects have been compared to those of [[cocaine]], since it commonly causes [[hypertension]] (elevated blood pressure) and [[tachycardia]] (elevated heart rate). Reported effects include: |
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*Feelings of [[euphoria]] |
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*Increased alertness |
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*Dialated [[pupil]]s |
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*Rapid breathing |
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*Increased heart Rate |
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The effects of methcathinone usually last from four to six hours. |
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==Use & Pharmacology== |
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Methcathinone is usually sold in quantities of one fourth of a [[gram]], 1 gram, 3.5 grams ("8-ball") or an [[ounce]] (28.35 grams). The powdered material comes packaged in [[paper]] packets (called bindles), [[vial|vials]] and [[plastic]] bags. Street prices are in the vicinity of $20.00 [[USD]] to $25.00 USD for one fourth of a gram, $100.00 USD for 1 gram, and $200 USD to $250.00 USD for 3.5 grams. |
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Anecdotal reports have provided some information on patterns |
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of methcathinone abuse. The most common route of [[administration]] |
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is via [[nasal]] [[insufflation]] ([[snorting]]). Other routes of administration include [[oral ingestion]], [[intravenous injection]] and [[smoking]]. |
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Methcathinone is abused in [[binge|binges]] lasting two to six days. During binges experienced users will administer methcathinone at doses ranging from one sixteenth to one fourth or a gram. The interval between dosing varies between approximately 20 minutes and two hours. With such a dosing regimen, during a binge methcathinone may be administered in daily amounts exceeding 1 or 2 grams. The principal determinant defining the length of the binge is the amount of drug available; that is, the binge ends only when the available supply of drug runs out. |
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The methcathinone binge resembles [[amphetamine]] binges |
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in that the abuser does not [[sleep]] or [[eat]], and takes in little in the way of [[liquids]]. The methcathinone binge is followed by a "crash" characterized by long periods of sleep, excess eating and, in some cases, [[clinical depression|depression]]. |
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==Street names== |
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Cat, Jeff, Bathtub Speed, Wannabe-Speed, Kitty, Meth's Cat, Meth's Kitten |
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In [[Europe]], methcathinone is primarily known as Ephedrone. |
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==Addiction== |
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In preclinical studies, methcathinone [[hydrochloride]] produces an abuse potential similar to that of the [[amphetamines]]. |
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Methcathinone can be highly [[addictive]], and can produce [[methamphetamine]]-like withdrawls. Most users do not experience [[addiction]] on their first use. |
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In [[drug]] [[discrimination]] studies, methcathinone hydrochloride evokes responses similar to those induced by both [[Amphetamine|(+)-amphetamine sulphate]] and [[cocaine]] hydrochloride. When examined in particular pharmacological assays for [[psychomotor]] [[stimulant]]-like activity, both the d and l [[enantiomeric]] forms of methcathinone hydrochloride have been found to be pharmacologically active. In these assays, the l- |
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form of methcathinone is more active than either d-methcathinone |
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or (+)-amphetamine. [[Racemic]] methcathinone hydrochloride is [[intravenous|intravenously]] self-administered by |
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[[baboon|baboons]], thus indicating that methcathinone produces reinforcing effects in this [[laboratory]] [[animal]], and suggesting that the drug has a potential for abuse in the human [[population]]. |
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==Clinical Use== |
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NONE: As a Schedule-1 drug, there is no legal clinical use. Research without a specific DEA permit is prohibited. |
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Futhermore, anecdotal reports from [[USENET]] posts in the 1990s indicate that unlike many stimulants, Methcathinone probably doesn't have the inhibitory effects seen in other controlled substance stimulants that make them useful as medications to treat [[Attention Deficit Disorder]] with or without Hyperactivity ([[ADHD]] / [[ADD]]). |
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It does promote [[weight loss]] in a manner similar to its sister drug [[methamphetamine]], but unlike [[methamphetamine]], cannot be prescribed by any doctor, for any reason, due to its legal classification. |
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==See also== |
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Other related phenethylamine drugs and plants: |
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* [[amphetamine]] |
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* [[ephedrine]] |
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* [[methamphetamine]] |
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* [[phenethylamine]] |
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* [[pseudoephedrine]] |
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Other CNS-active phenyl-ethylamino ketones (Drugs that contain the [[cathinone]] core structure): |
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* [[diethylpropion]] ([[Tenuate]]) |
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* [[bupropion]] ([[Wellbutrin]] aka [[Zyban]]) |
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* [[khat]] ([[cathinone]]) |
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==External links== |
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[http://www.erowid.org/chemicals/cathinone/cathinone.shtml Cathinone & Methcathinone from Erowid] |
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[http://paranoia.lycaeum.org/stimulants/59.FR.31639 Methcathinone from lycaeum] |
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{{DrugsNotice}} |
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[[Category:Amphetamines]] |
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[[Category:Class A drugs]] |
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[[Category:Class B drugs]] |
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[[Category:Phenethylamines]] |
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[[Category:Stimulants]] |
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[[Category:Schedule I controlled substances]] |
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{{Phenethylamines}} |
Latest revision as of 01:29, 24 March 2017
About me:
I live in Brisbane Queensland Australia.
My hobbies are :
Fascinating facts that I know:
Malcolm Turnbull is Prime Minister of Australia[1]
References:
- ^ "Prime Minister of Australia". Australian Government. Retrieved 24 March 2017.
{{cite web}}
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