St. Mary's Medical Center may refer to:
- St. Mary's Medical Center (San Francisco) — San Francisco, California
- St. Mary's Medical Center (West Palm Beach) - West Palm Beach, Florida
- St. Mary's Medical Center (Blue Springs) — Blue Springs, Missouri
- St. Mary's Medical Center (Knoxville) — Knoxville, Tennessee
- St. Mary's Medical Center (Huntington) — Huntington, West Virginia
- St. Mary's of Michigan Medical Center — Saginaw, Michigan
- St. Mary's Hospital Medical Center — Green Bay, Wisconsin
- St. Mary's Hospital and Medical Center — Evansville, Indiana
- St. Mary's Medical Center (Duluth, Minnesota) — Duluth, Minnesota
- St. Mary's Medical Center (Clearwater, FL) — Clearwater, Florida