Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1gene in humans.[5]
The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein is found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which contains beta and gamma subunits.[5]
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Greenfield JJ; High S (1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J. Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID10212142.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID14743216. S2CID11683986.