Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCGgene.[3][4]
Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is also cleaved into the following components in different organs:
Signal peptide (1-20) – removed from preproglucagon to form proglucagon